Ulrich G. Hofmann

Former Research Associate

Research Interests

HUMAN-MACHINE-INTERFACING

NEURO-ENGINEERING

Goal: Bridging the gap between experimental and simulation approaches for the neuro- and medical sciences.

• Novel high-performance and realtime data acquisition systems for many channels (and neurons).

• Realtime visualization, analysis and data mining in huge neuronal data volumes.

• Modelling of big realistic neuron networks.

CV

2008 Professor, University of Lübeck

2008 Call for a professorate in Biomedical Engineering/Neural Engineering, Reykjavik University, Iceland

2007 Co-Founder of "pro-MedTec GmbH", Lübeck, medical robotics

2005/06 Co-Author "Graduate School Lübeck", DFG-Exzellenzinitiative

2003 Habilitation in Computer Science

1999-2000 Member of the Board of Directors of BioTuL AG, München, Germany

since 1999    Research Associate, University of Lübeck

1997-1998 Postdoctoral Scholar, Feodor-Lynen-Fellow, Division of Biology, California Institute of Technology, Pasadena, CA. "Technology for multisite neuronal recordings"

1996 Research Associate, HCM-Fellow, Institutionen för Fysikalisk Kemi, Åbo Akademi, Turku, Finland. "Ultra-microscopy and surface functionalization of semiconducors"

1993-1996 Research Assistant; Physics Department, Technische Universität München.

Biosensors, ultra-microscopy, ultra-thin films, bio-functionalization, cell culture

1993-1994 Co-founder and part-time manager of the scientific services company MiNT, München

1992-1993 Graduation in Physics, Diploma. Technische Universität München.

Thesis: " Polymerizable diacetylene lipids on the air/water interface"

1987-1992 Undergraduate studies in Technical Physics, Technische Universität München. Specializing in medical electronics and medical radiological physics.

1985-1987 Officer track in the German Army medical service

 

1985 High School Graduation

 

2002

H. Schuhart, K. M. L. Menne, and U. G. Hofmann,
GROGRA and GENESIS: in computo grown neurons used for realistic compartmental modeling, in Poster and Abstract, CNS2002 , Chicago , 2002.
Bibtex: BibTeX
@INPROCEEDINGS{SchuhartCNR2002,
  author = {H. Schuhart and K. M. L. Menne and U. G. Hofmann},
  title = {GROGRA and GENESIS: in computo grown neurons used for realistic compartmental
	modeling},
  booktitle = {Poster and Abstract, CNS2002},
  year = {2002},
  address = {Chicago}
}
K. M. L. Menne, A. Folkers, T. Malina, R. Maex, and U. G. Hofmann,
Test of spike sorting algorithms on the basis of simulated network data, Neurocomputing 44-46 , vol. 44-46, pp. 1119-1126, 2002.
File: Menne_NEUCOM_01.pdf
Bibtex: BibTeX
@ARTICLE{MenneNEUCOM2002,
  author = {K. M. L. Menne and A. Folkers and T. Malina and R. Maex and U. G.
	Hofmann},
  title = {Test of spike sorting algorithms on the basis of simulated network
	data},
  journal = {Neurocomputing 44-46},
  year = {2002},
  volume = {44-46},
  pages = {1119-1126}
}
W. Freiwald, A. Wannig, A. K. Kreiter, U. G. Hofmann, M. D. Hills, G.T.A. Kovacs, D. T. Kewley, J. M. Bower, C. E. Eurich, and S. D. Wilke,
Stimulus representation in rat primary visual cortex: multi-electrode recordings with micromachined silicon probes and estimation theory, Neurocomputing , vol. 44-46, pp. 407-416, 2002.
File: Freiwald_NEUCOM_02.pdf
Bibtex: BibTeX
@ARTICLE{FreiwaldNEUCOM2002,
  author = {W. Freiwald and A. Wannig and A. K. Kreiter and U. G. Hofmann and M. D. Hills and G.T.A. Kovacs and D. T. Kewley and J. M. Bower and C. E. Eurich and S. D. Wilke},
  title = {Stimulus representation in rat primary visual cortex: multi-electrode recordings with micromachined silicon probes and estimation theory},
  journal = {Neurocomputing},
  year = {2002},
  volume = {44-46},
  pages = {407-416}
}
U. G. Hofmann, W. Jensen, K. Yoshida, M. Kindlundh, and P. Norlin,
Silizium-Vielfachsonden für die Neurowissenschaften, FOCUS MUL , vol. 19, no. 3, pp. 132-139, 2002.
File: Hofmann_FOCUS_MUL02_full_01.pdf
Bibtex: BibTeX
@ARTICLE{HofmannFocusMUL2002,
  author = {U. G. Hofmann and W. Jensen and K. Yoshida and M. Kindlundh and P. Norlin},
  title = {Silizium-Vielfachsonden für die Neurowissenschaften},
  journal = {FOCUS MUL},
  year = {2002},
  volume = {19},
  pages = {132-139},
  number = {3}
}
T. Malina, A. Folkers, and U. G. Hofmann,
Real-time EEG processing based on Wavelet Transformation, in IFMBE - 12th Nordic Baltic Conference on Biomedical Engineering and Medical Physics , Reykjavik , 2002.
File: Malina_NBC02-netz_01.pdf
Bibtex: BibTeX
@INPROCEEDINGS{MalinaNBC2002,
  author = {T. Malina and A. Folkers and U. G. Hofmann},
  title = {Real-time EEG processing based on Wavelet Transformation},
  booktitle = {IFMBE - 12th Nordic Baltic Conference on Biomedical Engineering and
	Medical Physics},
  year = {2002},
  address = {Reykjavik},
  organization = {International Federation for Medical \& Biological Engineering}
}
P. Norlin, M. Kindlundh, and U. Hofmann,
Probe suitable for use in neural tissue., .... Swedish Patent Pending 2002, European Patent Pending EP 1389442 A1, 2002.
Bibtex: BibTeX
@Book{HofmannSwedishPatent2002,
  title     = {Probe suitable for use in neural tissue},
  publisher = {Swedish Patent Pending 2002, European Patent Pending EP 1389442 A1},
  year      = {2002},
  author    = {Norlin, P. and Kindlundh, M. and Hofmann, U.},
}
U. G. Hofmann, U. Knopp, J. Modersitzki, and B. Fischer,
Navigationshilfsvorrichtung für neurochirurgische Eingriffe am menschlichen Gehirn, 2002. Eingereicht zum Deutschen Patent, DE 10242802.6.
Bibtex: BibTeX
@MISC{HofmannPatent2002,
  author = {U. G. Hofmann and U. Knopp and J. Modersitzki and B. Fischer},
  title = {Navigationshilfsvorrichtung für neurochirurgische Eingriffe am menschlichen
	Gehirn},
  howpublished = {Eingereicht zum Deutschen Patent, DE 10242802.6},
  year = {2002}
}
G. R. Biella, L. Uva, U. G. Hofmann, and M. deCurtis,
Intrinsic and associative synaptic circuit in the temporal neocortex, perirhinal and enotrhinal cortex: an intra- and extracellular electrophysiological study, in Forum of European Neurosciences - Abstracts , Paris , 2002.
File: FENS_Gerardo_01.pdf
Bibtex: BibTeX
@INPROCEEDINGS{BiellaFENS2002,
  author = {G. R. Biella and L. Uva and U. G. Hofmann and M. deCurtis},
  title = {Intrinsic and associative synaptic circuit in the temporal neocortex,
	perirhinal and enotrhinal cortex: an intra- and extracellular electrophysiological
	study},
  booktitle = {Forum of European Neurosciences - Abstracts},
  year = {2002},
  address = {Paris}
}
K. M. L. Menne, R. Maex, and U. G. Hofmann,
Biologically realistic simulated extracellular potential data as benchmark for the evaluation of spike detection algorithms, in Poster and Abstract, CNS2002 , Chicago , 2002.
Bibtex: BibTeX
@INPROCEEDINGS{MenneCNS2002,
  author = {K. M. L. Menne and R. Maex and U. G. Hofmann},
  title = {Biologically realistic simulated extracellular potential data as
	benchmark for the evaluation of spike detection algorithms},
  booktitle = {Poster and Abstract, CNS2002},
  year = {2002},
  address = {Chicago}
}
M. Kindlundh, P. Norlin, and U. G. Hofmann,
Development of multisite microelectrodes for neuroscience, in Proceedings of the Micro Structure Workshop MSW'02 , Aronsborg, Sweden , 2002. pp. B8.1-B8.6.
File: Kindlundh_MSW-02_01.pdf
Bibtex: BibTeX
@INPROCEEDINGS{KindlundhMWS2002,
  author = {M. Kindlundh and P. Norlin and U. G. Hofmann},
  title = {Development of multisite microelectrodes for neuroscience},
  booktitle = {Proceedings of the Micro Structure Workshop MSW'02},
  year = {2002},
  pages = {B8.1-B8.6},
  address = {Aronsborg, Sweden}
}
G. Biella, L. Uva, U. G. Hofmann, and M. deCurtis,
Associative interactions within the superficial layers of the entorhinal cortex of the guinea pig, J. Neurophysiology , vol. 88, no. 3, pp. 1159-1165, 2002.
File: Biella_JN2002_88_1159_01.pdf
Bibtex: BibTeX
@ARTICLE{Biella_JN88_2002,
  author = {G. Biella and L. Uva and U. G. Hofmann and M. deCurtis},
  title = {Associative interactions within the superficial layers of the entorhinal
	cortex of the guinea pig},
  journal = {J. Neurophysiology},
  year = {2002},
  volume = {88},
  pages = {1159-1165},
  number = {3}
}
K. M. L. Menne, R. Maex R, and U. G. Hofmann,
A realistical simulation of a small CA3 network to benchmark spike sorting algorithms and feature detection, in Poster and Abstract, Forum of European Neurosciences , Paris , 2002.
Bibtex: BibTeX
@INPROCEEDINGS{MenneFens2002,
  author = {Menne, K. M. L. and Maex R, R.  and  Hofmann, U. G.},
  title = {A realistical simulation of a small CA3 network to benchmark spike
	sorting algorithms and feature detection},
  booktitle = {Poster and Abstract, Forum of European Neurosciences},
  year = {2002},
  volume = {Abstr. vol.1, A090.12},
  address = {Paris}
}
P. Fagerstedt, A. Volny-Luraghi, M. Kindlundh, P. Norlin, U. Hofmann, and E. DeSchutter,
A new type of silicon probes with multi-site microelectrodes for single unit and local field potential (LFP) recordings from cerebellar cortex of anesthetized rats, in Forum of European Neurosciences - Abstracts. 2002 , Paris , 2002.
File: FENS_Patrik.pdf
Bibtex: BibTeX
@INPROCEEDINGS{FagerstedtFENS2002,
  author = {P. Fagerstedt and A. Volny-Luraghi and M. Kindlundh and P. Norlin
	and U. Hofmann and E. DeSchutter},
  title = {A new type of silicon probes with multi-site microelectrodes for
	single unit and local field potential (LFP) recordings from cerebellar
	cortex of anesthetized rats},
  booktitle = {Forum of European Neurosciences - Abstracts. 2002},
  year = {2002},
  address = {Paris}
}
M. Lipphard, F. Eberhardt, and U. G. Hofmann,
A Matlab program to quantify low-SNR pacemaker signals, in IFMBE - 12th Nordic Baltic Conference on Biomedical Engineering and Medical Physics. , Reykjavik , 2002.
File: Lipphard_NBC02_netz.pdf
Bibtex: BibTeX
@INPROCEEDINGS{LipphardNBC02,
  author = {M. Lipphard and F. Eberhardt and U. G. Hofmann},
  title = {A Matlab program to quantify low-SNR pacemaker signals},
  booktitle = {IFMBE - 12th Nordic Baltic Conference on Biomedical Engineering and
	Medical Physics.},
  year = {2002},
  address = {Reykjavik},
  organization = {International Federation for Medical \& Biological Engineering}
}
U. G. Hofmann, A. Folkers, F. Mösch, F. Höhl, M. Kindlundh, and P. Norlin,
A 64(128)-channel multisite neuronal recording system, Biomedizinische Technik , vol. 47(E 1), pp. 194-197, 2002.
File: Hofmann_BMT_01.pdf
Bibtex: BibTeX
@ARTICLE{HofmannBMT2002,
  author = {U. G. Hofmann and A. Folkers and F. Mösch and F. Höhl and M. Kindlundh and P. Norlin},
  title = {A 64(128)-channel multisite neuronal recording system},
  journal = {Biomedizinische Technik},
  year = {2002},
  volume = {47(E 1)},
  pages = {194-197}
}
P. Norlin, M. Kindlundh, A. Mouroux, K. Yoshida, W. Jensen, and U. G. Hofmann,
A 32-site neural recording probe fabricated by DRIE of SOI substrates, J. Micromechanics Microeng. , vol. 12, pp. 414-419, 2002.
File: Norlin_et_al__JMM_2002.pdf
Bibtex: BibTeX
@ARTICLE{NorlinJMM2002,
  author = {P. Norlin and M. Kindlundh and A. Mouroux and K. Yoshida and W. Jensen
	and U. G. Hofmann},
  title = {A 32-site neural recording probe fabricated by DRIE of SOI substrates},
  journal = {J. Micromechanics Microeng.},
  year = {2002},
  volume = {12},
  pages = {414-419}
}
K. M. L. Menne, T. Malina, and U. G. Hofmann,
Biologically realistic simulation of a part of hippocampal CA3: Generation of testdata for the evaluation of spike detection algorithms, in 5th German Workshop on Artificial Life - Abstracting and Synthesizing the Principles of Living Systems , D. Polani and J. Kim and T. Martinetz, Eds. Lübeck: IOS Press Infix, 2002. pp. 17-25.
File: Menne_GWAL5_01.pdf
Bibtex: BibTeX
@INPROCEEDINGS{MenneGWAL5-2002,
  author = {K. M. L. Menne and T. Malina and U. G. Hofmann},
  title = {Biologically realistic simulation of a part of hippocampal CA3: Generation
	of testdata for the evaluation of spike detection algorithms},
  booktitle = {5th German Workshop on Artificial Life - Abstracting and Synthesizing
	the Principles of Living Systems},
  year = {2002},
  editor = {D. Polani and J. Kim and T. Martinetz},
  pages = {17-25},
  address = {Lübeck},
  publisher = {IOS Press Infix}
}

2001

K. M. L. Menne, R. Maex, and U. G. Hofmann,
Extracellular potential data generated in a network simulation, in Poster and Abstract, The Neurosciences at the Turn of the Century, Proceedings of the 4th Meeting of the German Neuroscience Society , Göttingen: Georg Thieme Verlag, 2001.
Bibtex: BibTeX
@INPROCEEDINGS{MEN01a,
  author = {K. M. L. Menne and R. Maex and U. G. Hofmann},
  title = {Extracellular potential data generated in a network simulation},
  booktitle = {Poster and Abstract, The Neurosciences at the Turn of the Century,
	Proceedings of the 4th Meeting of the German Neuroscience Society},
  year = {2001},
  volume = {1},
  number = {602},
  address = {Göttingen},
  publisher = {Georg Thieme Verlag}
}
W. Jensen, T. Malina, U. G. Hofmann, and K. Yoshida,
Measurement of intrafascicular insertion force of a tungsten needle into peripheral nerve, in Proc. IEEE EMBS, PaperID 517, Istanbul, Turkey , Istanbul, Turkey , 2001.
File: Jensen_ieee2001.pdf
Bibtex: BibTeX
@INPROCEEDINGS{JensenIEEE01,
  author = {W. Jensen and T. Malina and U. G. Hofmann and K. Yoshida},
  title = {Measurement of intrafascicular insertion force of a tungsten needle
	into peripheral nerve},
  booktitle = {Proc. IEEE EMBS, PaperID 517, Istanbul, Turkey},
  year = {2001},
  address = {Istanbul, Turkey},
  note = {PaperID 517}
}
D. W. Britt, U. G. Hofmann, D. Möbius, and S. W. Hell,
Influence of substrate properties on the topochemical polymerization of diacetylene monolayers, Langmuir , vol. 17, pp. 3757-3765, 2001.
File: la001240v_Britt.pdf
Bibtex: BibTeX
@ARTICLE{LA17Britt2001,
  author = {D. W. Britt and U. G. Hofmann and D. Möbius and S. W. Hell},
  title = {Influence of substrate properties on the topochemical polymerization
	of diacetylene monolayers},
  journal = {Langmuir},
  year = {2001},
  volume = {17},
  pages = {3757-3765}
}
B. Weber, T. Malina, K. Menne, V. Metzler, A. Folkers, and U. G. Hofmann,
Handling large files of multisite microelectrode recordings for the European VSAMUEL consortium, Neurocomputing , vol. 38-40, pp. 1725-1734, 2001.
File: Weber-NEUCOM_01p.pdf
Bibtex: BibTeX
@ARTICLE{WeberNEUCOM01,
  author = {B. Weber and T. Malina and K. Menne and V. Metzler and A. Folkers
	and U. G. Hofmann},
  title = {Handling large files of multisite microelectrode recordings for the
	European VSAMUEL consortium},
  journal = {Neurocomputing},
  year = {2001},
  volume = {38-40},
  pages = {1725-1734}
}
K. Yoshida, W. Jensen, P. Norlin, M. Kindlundh, and U. G. Hofmann,
Characterization of silicon microelectrodes from the EU VSAMUEL project, Biomedizinsche Technik , vol. 46, no. E1, pp. 446-447, 2001.
File: Yoshida_BMT01.pdf
Bibtex: BibTeX
@ARTICLE{YoshidaBMT01,
  author = {K. Yoshida and W. Jensen and P. Norlin and M. Kindlundh and U. G.
	Hofmann},
  title = {Characterization of silicon microelectrodes from the EU VSAMUEL project},
  journal = {Biomedizinsche Technik},
  year = {2001},
  volume = {46},
  pages = {446-447},
  number = {E1}
}
U. G. Hofmann, J. Thompson, and D. T. Kewley,
Electrophysiological depth profiling by multiunit microelectrodes for stereotactic neurosurgery, 2001. US Patent No. 6,330,466, California Institute of Technology, USA.
Bibtex: BibTeX
@MISC{HOF01a,
  author = {U. G. Hofmann and J. Thompson and D. T. Kewley},
  title = {Electrophysiological depth profiling by multiunit microelectrodes
	for stereotactic neurosurgery},
  howpublished = {US Patent No. 6,330,466, California Institute of Technology, USA},
  year = {2001}
}
U. G. Hofmann, and J. Peltonen,
Colour transitions in monolayers of a polymerizable single chain diacetylenic lipid, Langmuir , vol. 17, pp. 1518-24, 2001.
File: la17-2001-Jouko.pdf
Bibtex: BibTeX
@ARTICLE{La17Jouko2001,
  author = {U. G. Hofmann and J. Peltonen},
  title = {Colour transitions in monolayers of a polymerizable single chain
	diacetylenic lipid},
  journal = {Langmuir},
  year = {2001},
  volume = {17},
  pages = {1518-24}
}
T. Malina, A. Folkers, F. Mösch, K. Labusch, M. Schürmann, and U. G. Hofmann,
An integrated system to trigger feedback-coupled event related brain potentials (ERPs), Biomedizinsche Technik , vol. 46, no. E1, pp. 322-323, 2001.
File: Malina_BMT01.netz_01.pdf
Bibtex: BibTeX
@ARTICLE{MalinaBMT2001,
  author = {T. Malina and A. Folkers and F. Mösch and K. Labusch and M. Schürmann
	and U. G. Hofmann},
  journal = {In: J. Werner (Ed.),  46 E1, , Schiele \& Sch{\"o}n GmbH, Bochum},
  title = {An integrated system to trigger feedback-coupled event related brain
	potentials (ERPs)},
  journal = {Biomedizinsche Technik},
  year = {2001},
  volume = {46},
  pages = {322-323},
  number = {E1}
}